<p>This study aimed to measure the effect of transformational leadership, knowledge management and work environment on performance of the employee of a packaging industry in Tangerang which are mediated by job satisfaction. Data collection was done by simple random sampling to 351 population of employees. The returned and valid questionnaire results were 221 samples. Data processing was used SEM method with SmartPLS 3.0 software. The results of this study concluded that transformational leadership and knowledge management have not significant effect on employee performance, both directly and indirectly through mediating job satisfaction. Meanwhile, work environment have a significant effect on employee performance, both directly and indirectly through mediating job satisfaction. Job satisfaction have a significant effect on employee performance. This new research proposed a model for building employee performance among the packaging industry employees in Tangerang through enhancing positive work environment and manage implementation of transformational leadership practice and knowledge management with job satisfaction as a mediator. This research could pave the way to improve employee readiness in facing the era of industrial revolution 4.0.</p>