These research aims to analyze the effect of Liquidity, Efficiency, Sales, and Leverage and also to analyze whether Tax Avoidance can make it strong or make it weak for relationship between independent and dependent variable (profit growth). The data from Morningstar official website, Indonesia Stock Exchange website, and sahamok.com website. The data was collected with the purposive sampling method, and get 25 manufacture companies that listed on Indonesia Stock Exchange in period 2014-2016. The analysist method that used in order to process the data using multiple linear regression method. The result from this research is, in stimulant ways the independent variable such as Liquidity, Efficiency, Sales, Leverage, and Tax Avoidance affected on profit growth, but in partial ways, the results shows that Sales affected on profit growth on manufactured companies that listed on Indonesia Stock Exchange for 2014-2016 period. For the result of the moderating test, shows that Tax Avoidance is a potential moderator variable it can be saw that there are increasing in Adjusted R Square value from before the Tax Avoidance include and after-Tax Avoidance include. Tax Avoidance can make the relationship between Liquidity, Efficiency, Sales, Leverage has strong effect on profit growth, on the manufactured companies that listed in Indonesia Stock Exchange for 2014-2016 period. From the result too shows that Liquidity, Efficiency, Sales, Leverage, Tax Avoidance only has 11.8% affected on profit growth, while the rest 88.2% affected by other factors that not including on this research. Discussion and limitation that include in this paper.