<p>This study aims to examine the relationship between technological orientation and innovation performance and the mediating role of entrepreneurial orientation in this relationship. It also aims to examine the direct and indirect effect of technological orientation on innovation performance within the proposed framework.  The research data were obtained from 156 senior and mid-level managers of  start-ups that are widely considered to be innovative, and that are listed among Indonesia’s largest 1,000 startup ranking. The data were analyzed using covariance-based structural equation modelling. Technological orientation entrepreneurial orientation had positive effects on innovation performance. Entrepreneurial orientation played a partial mediating role in the effect of technological orientation on innovation performance. In addition, indirect influence through mediation has a greater effect than direct influence. To increase the rate of innovation performance, top management of start-ups needs to support entrepreneurial behavior in the form of being proactive; innovative and risk-taking to all personnel. They also need to improve their technological capabilities to effectively transform market need into product innovation. The relationship between technological orientation and innovation performance using the mediating role of entrepreneurial orientation has not been examined in previous studies. This study is one of the first to contribute an integrated framework to raise the innovation performance of start-ups belonging to emerging countries. The managerial implication of this research emphasizes that firms must keep aligned acceleration of technology by acting proactively to produce innovative products and have risk-taking behaviour. Future research is expected to validate the premises confirmed in this study by using case studies on a single firm as a subject</p>