Employee performance is important for every institution. Employee performance can be influenced by factors of leadership, discipline, competence, and compensation. The purpose of this study is to analyze and determine the effect of leadership, discipline, competence, and compensation on employee performance. The population of this study were all employees of the Kampar District Health Office and all employees were sampled, so that the sample was taken using the census method. Hypotheses were tested using the F test and t test obtained from multiple linear regression equations. The results of this study prove that simultaneously and partially there is a significant effect of the variables of leadership, discipline, competence and compensation on employee performance, but the competency variable does not have a significant effect on employee performance. There is a strong positive relationship between the variables of leadership, discipline, competence and compensation with performance variables