<span lang="IN">An unfavorable organizational culture will result in less-than-optimal employee performance. This study aims to determine the effect of work motivation, work discipline, and career development on employee performance, which is mediated by organizational culture. Inferential analysis in this study was carried out using Partial Least squares (PLS)-based structural equation modeling (SEM). Based on the results of research at the Makassar Region V Airport Authority Office, it is known that there is a direct positive and significant influence between work motivation, work discipline, career development, and organizational culture on employee performance. Likewise, the influence of work discipline and career development variables has a positive and significant effect on employee performance, mediated by organizational culture. In contrast, the work motivation variable does not have a significant effect on employee performance if it is mediated by organizational culture</span>